About WASAbis
About improvement of the “decision-making ability (ability to correctly process information) /attentiveness,” which are parts of the cognitive functions
What is wasabi-derived6-MSITC(wasabi sulphorafane)?
6-MSITC(6-Methylsulfinyl Isothiocyanate) refers to the main health component contained in small quantities in the rhizome of wasabi. Therefore, it is derived from plants and is a phytochemical that plants produce to protect themselves from external enemies.
*Phytochemical…chemicals that plants produce to protect themselves from external enemies
Efficacy of 6-MSITC
6-MSITC has been shown to reduce oxidative stress during strenuous exercise, to demonstrate a skin-beautifying effect that reduces discoloration and freckles, and to have an anti-inflammatory effect that relieves pain in knee joints. A platelet aggregation inhibitory effect, which is expected to exhibit effects including improvement of blood circulation, has also been confirmed.
Reference: KINJIRUSHI Wasabi Functionality Laboratory, Functionality of Wasabi-sulfinylTM. Retrieved from http://www.wasabi-labo.jp/sulfinyl/function/
For middle and older-aged persons with no exercise habits
Results of animal studies have reported on the effects of 6-MSITC on cognitive functions. *1,2 As exercise routines improve brain functions *3,4, 37 healthy middle and older age males and females (Placebo group: 18, Wasabi-derived 6-MSITC Group: 19) with no routine exercise habits and with self-awareness of forgetfulness were given wasabi-derived 6-MSITC to investigate the effects on the brain functions. As a result, as displayed in the diagram to the left, the variations in the eighth-week indicated that the wasabi-derived 6-MSITC group showed improvements compared to the placebo group*5, and some cognitive functions such as decision-making ability *8 and attentiveness showed improvements. *7
Citing representative data from research reviews *9
*8 ability to accurately process information
*1
Ability to correctly process information
*2
Protective Effects of 6-(Methylsulfinyl)hexyl Isothiocyanate on A 1-42-Induced Cognitive Deficit, Oxidative Stress, Inflammation, and Apoptosis in Mice. Int. J. Mol. Sci. 19,2083-2102(2018)
*3
Neuroprotection by 6-(methylsulfinyl)hexyl isothiocyanate in a 6-hydroxydopamine mouse model of Parkinson’s disease. Brain Reserch: 1589,93-104(2014)
*4
Correlation between cognitive functions and exercise/physical activity in the elderly, 25th Health and Medical Science Research Grant Papers, 129-136 (2010)
*5
Acute moderate exercise elicits increased dorsolateral prefrontalactivation and improves cognitive performance with Stroop test. Neuroimage, 50, 1702-1710(2010)
*6
A placebo is a drug that contains no active ingredient (has no medicinal effect). It looks like a real drug, but does not contain any medicinal ingredients. It is a fake drug.
*7
p < 0.05 (2 samples, t-test)
*8
The effects of wasabi root extract rich in 6-(methylsulfinyl)hexyl isothiocyanateon neurocognitive functions in cognitively intact middle-aged and older adults: a randomized, double-blind, placebo-controlled trial. Jpn Pharmacol Ther. 47, 275-286 (2019). Report for systematic review
*9
Inhibitory Effects of 6-Methylsulfinylhexyl Isothiocyanate on Superoxide Anion Generation from Differentiated HL-60 Human Promyelocytic Leukemia Cells. Food Science and Technology Research, 23, 343-348(2017)
*10
All About Wasabi, Japan Scientific Societies Press (2006)
